Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy,
but the mechanisms remain unidentified. Here we provide evidence that poly (ADP-ribose) …

Poly (ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of
diabetes complications, is considered a downstream effector of oxidative-nitrosative stress …

Poly (ADP-ribose) polymerase (PARP) inhibition has recently been identified as a novel
approach to treatment of experimental peripheral diabetic neuropathy (PDN). However, long …

Poly (ADP-ribose) polymerase (PARP) activation is emerging as a fundamental mechanism
in the pathogenesis of diabetes complications including diabetic neuropathy. This study …

Evidence that poly (ADP-ribose) polymerase (PARP) activation plays an important role in
diabetic complications is emerging. This study evaluated the role of PARP in rat and mouse …

Activation of poly (ADP-ribose) polymerase (PARP) plays a role in the pathogenesis of β-cell
necrosis that occurs in response to autoimmune disease associated with Type I diabetes. In …

This study evaluated the role of poly (ADP-ribose) polymerase (PARP) in systemic oxidative
stress and 4-hydoxynonenal adduct accumulation in diabetic peripheral neuropathy. Control …

This study evaluated poly (ADP-ribose) polymerase (PARP) inhibition as a new therapeutic
approach for peripheral diabetic neuropathy using clinically relevant animal model and …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and a growing family of additional, novel poly (ADP-ribosylating) …

In diabetes, activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) is an
important effector of oxidative-nitrosative injury, which contributes to the development of …