Sonic hedgehog (Shh) signalling controls integrated specification of digit pattern and growth
in the chick wing but downstream gene networks remain to be unravelled. We analysed 3D …

Sonic hedgehog (Shh) signalling by the polarizing region at the posterior margin of the chick
wing bud is pivotal in patterning the digits but apart from a few key downstream genes, such …

Hoxd13, Tbx2, Tbx3, Sall1 and Sall3 genes are candidates for encoding antero-posterior
positional values in the developing chick wing and specifying digit identity. In order to build …

A fundamental question is how proliferation and growth are timed during embryogenesis.
Although it has been suggested that the cell cycle could be a timer, the underlying …

In the classical model of chick wing digit-patterning, the polarizing region—a group of cells
at the posterior margin of the early bud—produces a morphogen gradient, now known to be …

The organs of vertebrate species display a wide variety of morphology. A remaining
challenge in evolutionary developmental biology is to elucidate how vertebrate lineages …

In an influential model of pattern formation, a gradient of Sonic hedgehog (Shh) signalling in
the chick wing bud specifies cells with three antero-posterior positional values, which give …

Background: The organizing center, which serves as a morphogen source, has crucial
functions in morphogenesis in animal development. The center is necessarily located in a …

The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the
polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the …

Sonic Hedgehog (Shh) signaling by the polarizing region, at the posterior of the vertebrate
limb bud, is pivotal in determining digit number and identity. Shh establishes a gradient of …