Sonic hedgehog (Shh) signaling controls numerous aspects of vertebrate development,
including proliferation of precursors in different organs. Identification of molecules that link …

Wnt signaling is an important component in patterning the early embryo and specifically the
neural plate. Studies in Xenopus, mouse, and zebrafish have shown that signaling by …

Signalling cascades first described in Drosophila have been found to regulate patterning
and outgrowth in a number of structures in higher vertebrates. We sought to determine …

Hedgehog (Hh) signaling in vertebrates controls patterning and differentiation of a broad
range of tissues during development. The Hh receptor Patched (Ptc) is a critical regulator of …

We have analyzed a new limb mutant in the chicken that we name oligozeugodactyly (ozd).
The limbs of this mutant have a longitudinal postaxial defect, lacking the posterior element in …

In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins interact with
chromosomal elements, termed Cellular Memory Modules (CMMs). By modifying chromatin …

The signalling molecule Sonic hedgehog (Shh) controls a wide range of differentiation
processes during vertebrate development. Numerous studies have suggested that the …

Sonic hedgehog (Shh) signals via Gli transcription factors to direct digit number and identity
in the vertebrate limb. We characterized the Gli-dependent cis-regulatory network through a …

Development of the musculature in chick limbs involves tissue and cellular patterning.
Patterning at the tissue level leads to the precise arrangement of specific muscles; at the …

During the past decade, a small number of families of secreted proteins have emerged as
key regulators of many of the important inductive interactions that control the development of …