The Hedgehog signaling pathway has been recognized as essential for patterning
processes in development of metazoan animal species. The signaling pathway is, however …

Sonic hedgehog (Shh) patterns the dorsal‐ventral axis of the neural tube by promoting the
differentiation of ventral neural cell types while suppressing dorsal neural fates. Other …

The zinc‐finger transcription factor GLI3 acts during vertebrate development in a
combinatorial, context‐dependent fashion as a primary transducer of sonic hedgehog (SHH) …

The secreted factor Sonic hedgehog (SHH) is both required for and sufficient to induce
multiple developmental processes, including ventralization of the CNS, branching …

Sonic hedgehog (Shh) signaling is essential for the anterior-posterior (AP) patterning of the
embryonic limb bud. An additional role for Shh has now been identified in the mouse and …

Background The zinc-finger transcription factor GLI3 is an important mediator of Sonic
hedgehog signaling and crucial for patterning of many aspects of the vertebrate body plan …

Limb patterning by Sonic hedgehog (Shh), via either graded spatial or temporal signal
integration, is a paradigm for" morphogen" function, yet how Shh instructs distinct digit …

The hedgehog (hh) segmentation gene of Drosophila melanogaster encodes a secreted
signaling protein that functions in the patterning of larval and adult structures. Using low …

The segment polarity genes play a fundamental role in the patterning of cells within
individual body segments of the Drosophila embryo. Two of these genes wingless (wg) and …

A gradient of Sonic hedgehog (Shh) plays a major role in specifying the antero‐posterior
pattern of structures that develop in the distal part of the vertebrate limb, in particular, the …