The hedgehog family of intercellular signalling molecules have essential functions in
patterning both Drosophila and vertebrate embryos. Drosophila has a single hedgehog …

Background: The hedgehog (hh) family of secreted signaling proteins is responsible for
developmental patterning in a variety of systems, including the neural tube, limbs and …

Sonic Hedgehog (SHH) plays a fundamental role in numerous developmental processes
including morphogenesis of limbs, nervous system, and teeth. Using a Bayesian alignment …

Understanding the mechanisms that regulate gene expression during development is a
major challenge in science. In this issue of Developmental Cell, Amano and colleagues …

The secreted molecule Sonic hedgehog (Shh) is crucial for floor plate and ventral brain
development in amniote embryos. In zebrafish, mutations in cyclops (cyc), a gene that …

Patterning of the limb is coordinated by the complex interplay of three signaling regions: the
apical ectodermal ridge (AER), the zone of polarizing activity (ZPA), and the non-ridge limb …

The membrane protein, Patched, plays a critical role in patterning embryonic and imaginal
tissues in Drosophila. patched constitutively inactivates the transcription of target genes …

Sonic hedgehog (SHH) plays a central role in patterning numerous embryonic tissues
including, classically, the developing limb bud where it controls digit number and identity …

Signaling between cells in the anterior (A) and posterior (P) compartments directs
Drosophila wing disc development and is dependent on expression of the homeodomain …

We have produced detailed fate maps for mesenchyme and apical ridge of a stage 20 chick
wing bud. The fate maps of the mesenchyme show that most of the wing arises from the …