Abstract Background The Caenorhabditis elegans genome encodes ten proteins that share
sequence similarity with the Hedgehog signaling molecule through their C-terminal …

In Drosophila, maintenance of parasegmental boundaries and formation of segmental
grooves depend on interactions between segment polarity genes. Wingless and Engrailed …

The past decade has seen a revolution in our understanding of the molecular basis of
embryonic development in higher organisms. As our understanding of vertebrate …

The expression domains of genes located at the 5′ end of the HoxD (formerly Hox-4)
complex appear to correlate with pattern along both the proximal-distal (PrDi) and the …

Background The notochord has organizer properties and is required for floor plate induction
and dorsoventral patterning of the neural tube. This activity has been attributed to sonic …

Quantitative analysis of gene expression domains and investigation of relationships
between gene expression and developmental and phenotypic outcomes are central to …

The spatial organization of cell fates in developing tissues often involves the control of
transcriptional networks by morphogen gradients. A well-studied example of this is the Sonic …

Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord,
which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous …

Sonic hedgehog (Shh) plays an integral role in both the anterior-posterior (AP) patterning
and expansion of developing vertebrate limbs through a feedback loop involving Fgfs …

Anterior–posterior (A/P) limb patterning in vertebrates is determined by the counteraction
between the Sonic Hedgehog (Shh) and the Gli3 transcription factor. Shh exerts its effect on …