Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties
The origin and evolution of the complex regulatory landscapes of some vertebrate
developmental genes, often spanning hundreds of Kbp and including neighboring genes …
developmental genes, often spanning hundreds of Kbp and including neighboring genes …
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
E Laufer, CE Nelson, RL Johnson, BA Morgan, C Tabin - Cell, 1994 - cell.com
Serial sections of individual embryos of a staged series were hybridized with radioactive
probes for Sonic hedgehog, Hoxd-IO, Hoxd-? I, and Hoxd-72 Several embryos were …
probes for Sonic hedgehog, Hoxd-IO, Hoxd-? I, and Hoxd-72 Several embryos were …
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
C Chiang, Y Litingtung, MP Harris, BK Simandl… - Developmental …, 2001 - Elsevier
The secreted protein encoded by the Sonic hedgehog (Shh) gene is localized to the
posterior margin of vertebrate limb buds and is thought to be a key signal in establishing …
posterior margin of vertebrate limb buds and is thought to be a key signal in establishing …
Protein kinase A and hedgehog signaling in Drosophila limb development
The Drosophila hedgehog (hh) gene encodes a secreted protein involved in organizing
growth and patterning in many developmental processes. Hh appears to act by inducing the …
growth and patterning in many developmental processes. Hh appears to act by inducing the …
Sonic hedgehog in vertebrate neural tube development
The formation and wiring of the vertebrate nervous system involves the spatially and
temporally ordered production of diverse neuronal and glial subtypes that are molecularly …
temporally ordered production of diverse neuronal and glial subtypes that are molecularly …
Divergent transcriptional regulatory logic at the intersection of tissue growth and developmental patterning
The Yorkie/Yap transcriptional coactivator is a well-known regulator of cellular proliferation
in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding …
in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding …
[引用][C] Posterior Hox gene expression in developing genitalia
C Podlasek, J Houston, KE McKenna… - Evolution & …, 2002 - Wiley Online Library
The process of development requires a complex interaction between the mesenchyme and
epithelium. The cascade of signaling molecules that controls signaling between tissue …
epithelium. The cascade of signaling molecules that controls signaling between tissue …
[HTML][HTML] Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms
A Pachikara, DK Dolson, L Martinu… - Developmental …, 2007 - Elsevier
The partitioning of the ventral neural tube into five distinct neuronal progenitor domains is
dependent on the morphogenic action of the secreted protein Sonic hedgehog (Shh). The …
dependent on the morphogenic action of the secreted protein Sonic hedgehog (Shh). The …
[HTML][HTML] Hoxd13 binds in vivo and regulates the expression of genes acting in key pathways for early limb and skeletal patterning
5′ HoxD genes are required for the correct formation of limb skeletal elements. Hoxd13, the
most 5′-located HoxD gene, is important for patterning the most distal limb region, and its …
most 5′-located HoxD gene, is important for patterning the most distal limb region, and its …
Regulation of patched by sonic hedgehog in the developing neural tube.
V Marigo, CJ Tabin - … of the National Academy of Sciences, 1996 - National Acad Sciences
Ventral cell fates in the central nervous system are induced by Sonic hedgehog, a homolog
of hedgehog, a secreted Drosophila protein. In the central nervous system, Sonic hedgehog …
of hedgehog, a secreted Drosophila protein. In the central nervous system, Sonic hedgehog …