Emerging evidence indicates that CD8+ and CD4+ T-cell immunity is differentially regulated.
Here we have delineated differences and commonalities among antiviral T-cell responses …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8
α-chain (CD8α) are localized permanently in lymphoid organs, whereas' tissue-derived DCs' …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …

We show here that T cell cross-reactivity between heterologous viruses influences the
immunodominance of virus-specific CD8+ T cells by two mechanisms. First, T cells specific …

Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination,
protect the host against specific viral infections. It has long been proposed that the number of …

Efficient boosting of memory T-cell numbers to protective levels generally requires a
relatively long interval between immunizations. Decreasing this interval could be crucial in …

Functional impairment of antigen-specific T cells is a defining characteristic of many chronic
infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To …

In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise
memory-like and terminally exhausted subsets. However, little is known about the molecular …

Abstract Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR)
repertoire were examined during the course of HIV infection and following therapy. A …