Reduction in muscarinic receptor binding in limbic areas of Alzheimer brain.

JO Rinne, JK Rinne, K Laakso, L Paljärvi… - Journal of Neurology …, 1984 - ncbi.nlm.nih.gov
[30][24][8][16]* p< 0-05, tp 0-01,* p 0-001 compared with cont Number of patients in brackets
in the number of receptors (Bmax (fmoV mg prot.) 473+ 21-1 for controls and 352+ 28-0 for …

Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex

KJ Kellar, PJ Whitehouse, AM Martino-Barrows… - Brain research, 1987 - Elsevier
The total population of muscarinic receptors and a subpopulation of muscarinic receptors
with high affinity for agonists were measured with [3 H] quinuclidinyl benzilate and [3 H] …

Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: an autoradiographic study

A Probst, R Cortés, J Ulrich, JM Palacios - Brain research, 1988 - Elsevier
We have used quantitative light microscopic autoradiographic techniques to analyze
changes in muscarinic cholinergic receptors in the hippocampus in Alzheimer type dementia …

Muscarinic cholinoceptive neurons in the frontal cortex in Alzheimer's disease

H Schröder, E Giacobini, RG Struble, PGM Luiten… - Brain research …, 1991 - Elsevier
The cellular distribution of muscarinic acetylcholine receptor protein in the frontal cortex of
Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

Cholinergic receptors in cognitive disorders

EK Perry, RH Perry, CJ Smith, D Purohit… - Canadian Journal of …, 1986 - cambridge.org
Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have
been examined in the hippocampus obtained at autopsy from a variety of patients with …

Brain nicotinic and muscarinic receptors in normal aging and dementia

A Nordberg, B Winblad - … and Parkinson's Disease: Strategies for Research …, 1986 - Springer
The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases.

EK Perry, RH Perry, CJ Smith, DJ Dick… - Journal of Neurology …, 1987 - jnnp.bmj.com
The status of cholinergic receptors in dementia is related to the question of potential
cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or …

Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders

CJ Smith, EK Perry, RH Perry, JM Candy… - Journal of …, 1988 - Wiley Online Library
Total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for
pirenzepine, and the high‐and low‐affinity agonist states of the receptor were investigated in …

[引用][C] Cholinergic treatments for Alzheimer's disease

F ROBERTS, S LAZARENO - Biochemical Society Transactions, 1989 - portlandpress.com
FlONA ROBERTS and SEBASTIAN LAZARENO There is a correlation between the reduced
choline acctyl-Depcrrtmetif of Neirrophurmacolo&y, Gluxo Groirp lieserrrch, transferase …

Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

R Quirion - Journal of Psychiatry and Neuroscience, 1993 - ncbi.nlm.nih.gov
The status of various cholinergic markers was compared in Alzheimer's and Parkinson's
diseases. Rather unexpectedly, similar decrements were observed in choline …