Phosphorylation of IκB by the IκB kinase (IKK) complex is a critical step leading to IκB
degradation and activation of transcription factor NF-κB. The IKK complex contains two …

The transcription factor NF-κB coordinates the activation of numerous genes in response to
pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of …

Pro-inflammatory cytokines activate the transcription factor NF-κB by stimulating the activity
of a protein kinase that phosphorylates IκB, an inhibitor of NF-κB,,,,, at sites that trigger its …

NF-κB is a principal transcriptional regulator of diverse cytokine-mediated processes and is
tightly controlled by the IκB kinase complex (IKK-α/β/γ). IKK-β and IKK-γ are critical for …

IκB [inhibitor of nuclear factor κB (NF-κB)] kinase (IKK) phosphorylates IκB inhibitory
proteins, causing their degradation and activation of transcription factor NF-κB, a master …

Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and
molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the …

Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which
inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out …

Cytokine-induced activation of the IκB kinases (IKK) IKK-α and IKK-β is a key step involved
in the activation of the NF-κB pathway,,,. Gene-disruption studies of the murine IKK genes …

A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK)
complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional …

NF-κB is sequestered in the cytoplasm by the inhibitory IκB proteins. Stimulation of cells by
agonists leads to the rapid phosphorylation of IκBs leading to their degradation that results …