CRISPR/Cas9 genome editing for tissue‐specific in vivo targeting: nanomaterials and translational perspective

DK Sahel, LK Vora, A Saraswat, S Sharma… - Advanced …, 2023 - Wiley Online Library
Clustered randomly interspaced short palindromic repeats (CRISPRs) and its associated
endonuclease protein, ie, Cas9, have been discovered as an immune system in bacteria …

Key considerations in designing CRISPR/Cas9-carrying nanoparticles for therapeutic genome editing

Y Xu, R Liu, Z Dai - Nanoscale, 2020 - pubs.rsc.org
CRISPR-Cas9, the breakthrough genome-editing technology, has emerged as a promising
tool to prevent and cure various diseases. The efficient genome editing technology strongly …

Pre-clinical non-viral vectors exploited for in vivo CRISPR/Cas9 gene editing: An overview

N Rouatbi, T McGlynn, KT Al-Jamal - Biomaterials Science, 2022 - pubs.rsc.org
Clustered regulatory interspaced short palindromic repeats or CRISPR/Cas9 has emerged
as a potent and versatile tool for efficient genome editing. This technology has been …

Carrier strategies boost the application of CRISPR/Cas system in gene therapy

Z Xu, Q Wang, H Zhong, Y Jiang, X Shi, B Yuan… - …, 2022 - Wiley Online Library
Emerging clustered regularly interspaced short palindromic repeat/associated protein
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

L Li, S Hu, X Chen - Biomaterials, 2018 - Elsevier
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …

Nano-vectors for CRISPR/Cas9-mediated genome editing

P Yang, AYT Lee, J Xue, SJ Chou, C Lee, P Tseng… - Nano Today, 2022 - Elsevier
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-
associated protein 9 (CRISPR/Cas9) genome editing system has revolutionized the field of …

A CRISPR/Cas9 based polymeric nanoparticles to treat/inhibit microbial infections

R Verma, R Sahu, DD Singh, TE Egbo - Seminars in cell & developmental …, 2019 - Elsevier
The latest breakthrough towards the adequate and decisive methods of gene editing tools
provided by CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic …

Delivery of CRISPR/Cas9 by novel strategies for gene therapy

L Wang, W Zheng, S Liu, B Li, X Jiang - ChemBioChem, 2019 - Wiley Online Library
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …

Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing

H Tang, X Zhao, X Jiang - Advanced drug delivery reviews, 2021 - Elsevier
The clustered regularly interspaced short palindromic repeat (CRISPR) has great potential
to revolutionize biomedical research and disease therapy. The specific and efficient genome …

Development of delivery strategies for CRISPR‐Cas9 genome editing

Q Liu, J Yang, Y Xing, Y Zhao, Y Liu - BMEMat, 2023 - Wiley Online Library
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR‐
related protein 9 (Cas9) genome editing system has attracted much attention due to its …