Osteoblasts have recently been found to play a role in regulating glucose metabolism
through secretion of osteocalcin. It is unknown, however, how this osteoblast function is …

The Forkhead transcription factor FoxO1 inhibits through its expression in osteoblasts β-cell
proliferation, insulin secretion, and sensitivity. At least part of the FoxO1 metabolic functions …

The FoxO family of forkhead transcription factors is at the crossroads of many signal
transduction pathways that are evolutionarily conserved. Such pathways have been co …

FoxO1, one of the four FoxO isoforms of Forkhead transcription factors, is highly expressed
in insulin-responsive tissues, including pancreas, liver, skeletal muscle and adipose tissue …

Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to
stimulation by bone morphogenetic proteins. Studies presented here examined the …

In this study, we determined the molecular mechanisms whereby forkhead transcription
factor Foxo1, a key downstream signaling molecule of insulin-like growth factor 1 …

Skeletogenesis depends on the activity of bone-forming cells derived from mesenchymal
cells. The pathways that control mesenchymal cell differentiation are not well understood …

Osteoporosis, a disease of low bone mass, is associated with decreased osteoblast
numbers and increased levels of oxidative stress within osteoblasts. Since transcription …

The FoxO subfamily of forkhead transcription factors plays a critical role in a variety of
physiological processes including metabolism, differentiation, proliferation, apoptosis and …

Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved
transcription factors for their highly conserved DNA-binding domain. In mammalian species …