Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling

B Kamlage, SG Maldonado, B Bethan, E Peter… - Clinical …, 2014 - academic.oup.com
BACKGROUND Metabolomics is a valuable tool with applications in almost all life science
areas. There is an increasing awareness of the essential need for high-quality biospecimens …

Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies

G Theodoridis, HG Gika… - Mass spectrometry reviews, 2011 - Wiley Online Library
Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …

Challenges in mass spectrometry based targeted metabolomics

T Koal, HP Deigner - Current molecular medicine, 2010 - ingentaconnect.com
The gap of the post-genomic era is increasingly being filled by the metabolomics approach,
comprising a technology for analyzing small molecule endogenous metabolites (≤ 1500 …

Expanding coverage of the metabolome for global metabolite profiling

O Yanes, R Tautenhahn, GJ Patti… - Analytical chemistry, 2011 - ACS Publications
Mass spectrometry-based metabolomics is the comprehensive study of naturally occurring
small molecules collectively known as the metabolome. Given the vast structural diversity …

Analysis of the adult human plasma metabolome

KA Lawton, A Berger, M Mitchell, KE Milgram… - …, 2008 - Taylor & Francis
Objective: It is well established that disease states are associated with biochemical changes
(eg, diabetes/glucose, cardiovascular disease/cholesterol), as are responses to chemical …

Recent advances in LC‐MS‐based metabolomics for clinical biomarker discovery

CJ Chen, DY Lee, J Yu, YN Lin… - Mass spectrometry …, 2023 - Wiley Online Library
The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …

Mass spectrometry strategies for clinical metabolomics and lipidomics in psychiatry, neurology, and neuro-oncology

PL Wood - Neuropsychopharmacology, 2014 - nature.com
Metabolomics research has the potential to provide biomarkers for the detection of disease,
for subtyping complex disease populations, for monitoring disease progression and therapy …

Dealing with the unknown: metabolomics and metabolite atlases

BP Bowen, TR Northen - Journal of the American Society for Mass …, 2010 - Springer
Metabolomics is the comprehensive profiling of the small molecule composition of a
biological sample. Since metabolites are often the indirect products of gene expression, this …

Understanding metabolomics in biomedical research

SJ Kim, SH Kim, JH Kim, S Hwang… - Endocrinology and …, 2016 - synapse.koreamed.org
The term" omics" refers to any type of specific study that provides collective information on a
biological system. Representative omics includes genomics, proteomics, and metabolomics …

Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases

L Cui, H Lu, YH Lee - Mass spectrometry reviews, 2018 - Wiley Online Library
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …