Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling
B Kamlage, SG Maldonado, B Bethan, E Peter… - Clinical …, 2014 - academic.oup.com
BACKGROUND Metabolomics is a valuable tool with applications in almost all life science
areas. There is an increasing awareness of the essential need for high-quality biospecimens …
areas. There is an increasing awareness of the essential need for high-quality biospecimens …
Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies
G Theodoridis, HG Gika… - Mass spectrometry reviews, 2011 - Wiley Online Library
Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …
biology. To perform metabolomics it is necessary to generate comprehensive “global” …
Challenges in mass spectrometry based targeted metabolomics
T Koal, HP Deigner - Current molecular medicine, 2010 - ingentaconnect.com
The gap of the post-genomic era is increasingly being filled by the metabolomics approach,
comprising a technology for analyzing small molecule endogenous metabolites (≤ 1500 …
comprising a technology for analyzing small molecule endogenous metabolites (≤ 1500 …
Expanding coverage of the metabolome for global metabolite profiling
Mass spectrometry-based metabolomics is the comprehensive study of naturally occurring
small molecules collectively known as the metabolome. Given the vast structural diversity …
small molecules collectively known as the metabolome. Given the vast structural diversity …
Analysis of the adult human plasma metabolome
KA Lawton, A Berger, M Mitchell, KE Milgram… - …, 2008 - Taylor & Francis
Objective: It is well established that disease states are associated with biochemical changes
(eg, diabetes/glucose, cardiovascular disease/cholesterol), as are responses to chemical …
(eg, diabetes/glucose, cardiovascular disease/cholesterol), as are responses to chemical …
Recent advances in LC‐MS‐based metabolomics for clinical biomarker discovery
The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …
targeted metabolomics has led to the discovery of novel biomarkers and improved the …
Mass spectrometry strategies for clinical metabolomics and lipidomics in psychiatry, neurology, and neuro-oncology
PL Wood - Neuropsychopharmacology, 2014 - nature.com
Metabolomics research has the potential to provide biomarkers for the detection of disease,
for subtyping complex disease populations, for monitoring disease progression and therapy …
for subtyping complex disease populations, for monitoring disease progression and therapy …
Dealing with the unknown: metabolomics and metabolite atlases
BP Bowen, TR Northen - Journal of the American Society for Mass …, 2010 - Springer
Metabolomics is the comprehensive profiling of the small molecule composition of a
biological sample. Since metabolites are often the indirect products of gene expression, this …
biological sample. Since metabolites are often the indirect products of gene expression, this …
Understanding metabolomics in biomedical research
SJ Kim, SH Kim, JH Kim, S Hwang… - Endocrinology and …, 2016 - synapse.koreamed.org
The term" omics" refers to any type of specific study that provides collective information on a
biological system. Representative omics includes genomics, proteomics, and metabolomics …
biological system. Representative omics includes genomics, proteomics, and metabolomics …
Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …