Glycosaminoglycan (GAG) side chains endow extracellular matrix proteoglycans with
diversity and complexity based upon the length, composition and charge distribution of the …

Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons
in the central nervous system (CNS), but the structural diversity of their polysaccharides has …

Publisher Summary This chapter discusses the structure characterization and active site
chemistry of chondroitinases and their implication for advancing knowledge on the …

Publisher Summary This chapter discusses methods for the isolation and purification of
chondroitin sulfate (CS). This molecule is a sulfated glycosaminoglycan (GAG) composed of …

Background Sulfated glycosaminoglycan chains are known for their regulatory functions
during neural development and regeneration. However, it is still unknown whether the …

Neurite outgrowth is a critical but challenging function for the regeneration of impaired
neurons. Chondroitin sulfate (CS) plays key roles in regulating cellular behaviors of …

Chondroitin sulfate proteoglycans (CSPGs) are up‐regulated in glial scar tissue and inhibit
axon regeneration. Not only are the protein cores up‐regulated, but also there is more …

Chondroitin sulphate proteoglycans (CSPGs) are up‐regulated in the CNS after injury and
inhibit axon regeneration mainly through their glycosaminoglycan (CS‐GAG) chains. We …

The role of glycosaminoglycan sulfation patterns, particularly in regard to scar formation and
inhibition of neuritogenesis, has been mainly studied in cell culture with a focus on …

Publisher Summary This chapter reviews the structural characteristics of various chondroitin
sulfate (CS) chains and their binding activity toward growth factors based on available data …