The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis

T Aguado, E Romero, K Monory, J Palazuelos… - Journal of Biological …, 2007 - ASBMB
Endocannabinoids are lipid signaling mediators that exert an important neuromodulatory
role and confer neuroprotection in several types of brain injury. Excitotoxicity and stroke can …

Non‐psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation

J Palazuelos, T Aguado, A Egia… - The FASEB …, 2006 - Wiley Online Library
Cannabinoids, the active components of marijuana and their endogenous counterparts, act
on the brain and many other organs through the widely expressed CB1 cannabinoid …

Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling

E Molina-Holgado, JM Vela… - Journal of …, 2002 - Soc Neuroscience
Cannabinoids exert pleiotropic actions in the CNS, including the inhibition of inflammatory
responses and the enhancement of neuronal survival after injury. Although cannabinoid …

Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

C Compagnucci, S Di Siena, MB Bustamante… - PloS one, 2013 - journals.plos.org
Neural stem cells (NSCs) are self-renewing cells that can differentiate into multiple neural
lineages and repopulate regions of the brain after injury. We have investigated the role of …

CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling

S Trazzi, M Steger, VM Mitrugno, R Bartesaghi… - Journal of Biological …, 2010 - ASBMB
The endocannabinoid system is involved in the regulation of many physiological effects in
the central and peripheral nervous system. Recent findings have demonstrated the …

CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling

J Palazuelos, Z Ortega, J Díaz-Alonso… - Journal of Biological …, 2012 - ASBMB
The endocannabinoid system is known to regulate neural progenitor (NP) cell proliferation
and neurogenesis. In particular, CB 2 cannabinoid receptors have been shown to promote …

Mechanisms of control of neuron survival by the endocannabinoid system

I Galve-Roperh, T Aguado… - Current …, 2008 - ingentaconnect.com
Endocannabinoids act as retrograde messengers that, by inhibiting neurotransmitter release
via presynaptic CB1 cannabinoid receptors, regulate the functionality of many synapses. In …

The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells

T Aguado, J Palazuelos, K Monory, N Stella… - Journal of …, 2006 - Soc Neuroscience
Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid
CB1 receptors and may also participate in the control of neural cell death and survival. The …

Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development

I Galve-Roperh, T Aguado, D Rueda… - Current …, 2006 - ingentaconnect.com
The endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol are important
retrograde messengers that inhibit neurotransmitter release via presynaptic CB1 receptors …

The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway

D Rueda, B Navarro, A Martı́nez-Serrano… - Journal of Biological …, 2002 - ASBMB
Endocannabinoids are neuromodulators that act as retrograde synaptic messengers
inhibiting the release of different neurotransmitters in cerebral areas such as hippocampus …