Most epigenome-wide association studies to date have been conducted in blood. However,
metabolic syndrome is mediated by a dysregulation of adiposity and therefore it is critical to …

Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …

Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …

Background Elevated adiposity is often posited by medical and public health researchers to
be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These …

Background Obesity is an established risk factor for several common chronic diseases such
as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the …

Objective/methods DNA methylation plays an important role in obesity and related metabolic
complications. We examined genome-wide DNA promoter methylation along with mRNA …

Objective To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …

Background: Adiposity is a risk factor for type 2 diabetes and cardiovascular disease,
suggesting an important role for adipose tissue in the development of these conditions. The …

Little is known about the extent to which interactions between genetics and epigenetics may
affect the risk of complex metabolic diseases and/or their intermediary phenotypes. We …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency …