Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian …
Background The prevalence of obesity and its related chronic diseases have been
increasing especially in Asian countries. Obesity-related genetic variants have been …
increasing especially in Asian countries. Obesity-related genetic variants have been …
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …
epigenetic modifications associated with elevated adiposity, including DNA methylation …
Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals
D Macartney-Coxson, MC Benton, R Blick… - Clinical …, 2017 - Springer
Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …
and the genome and are known to play a role in complex diseases such as obesity. These …
Sample preparation to bioinformatics analysis of DNA methylation: association strategy for obesity and related trait studies
NY Noronha, G da Silva Rodrigues… - JoVE (Journal of …, 2022 - jove.com
Obesity is directly connected to lifestyle and has been associated with DNA methylation
changes that may cause alterations in the adipogenesis and lipid storage processes …
changes that may cause alterations in the adipogenesis and lipid storage processes …
Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes
DNA methylation variations are prevalent in human obesity but evidence of a causative role
in disease pathogenesis is limited. Here, we combine epigenome-wide association and …
in disease pathogenesis is limited. Here, we combine epigenome-wide association and …
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
S Voisin, MS Almén, GY Zheleznyakova, L Lundberg… - Genome medicine, 2015 - Springer
Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …
The epigenomic analysis of human obesity
CG Bell - Obesity, 2017 - Wiley Online Library
Objective Analysis of the epigenome—the chemical modifications and packaging of the
genome that can influence or indicate its activity—enables molecular insight into cell type …
genome that can influence or indicate its activity—enables molecular insight into cell type …
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …
The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Background Obesity is associated with changes in fat cell gene expression and metabolism.
What drives these changes is not well understood. We aimed to explore fat cell epigenetics …
What drives these changes is not well understood. We aimed to explore fat cell epigenetics …
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic …
Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …
diseases. However, the impact of these factors on the genome-wide DNA methylation …