Background The prevalence of obesity and its related chronic diseases have been
increasing especially in Asian countries. Obesity-related genetic variants have been …

Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Background Epigenetic mechanisms provide an interface between environmental factors
and the genome and are known to play a role in complex diseases such as obesity. These …

Obesity is directly connected to lifestyle and has been associated with DNA methylation
changes that may cause alterations in the adipogenesis and lipid storage processes …

DNA methylation variations are prevalent in human obesity but evidence of a causative role
in disease pathogenesis is limited. Here, we combine epigenome-wide association and …

Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …

Objective Analysis of the epigenome—the chemical modifications and packaging of the
genome that can influence or indicate its activity—enables molecular insight into cell type …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Background Obesity is associated with changes in fat cell gene expression and metabolism.
What drives these changes is not well understood. We aimed to explore fat cell epigenetics …

Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …