Increased age, BMI and HbA1c levels are risk factors for several non-communicable
diseases. However, the impact of these factors on the genome-wide DNA methylation …

Background There is considerable evidence for the importance of the DNA methylome in
metabolic health, for example, a robust methylation signature has been associated with …

Dysregulation of circulating lipids is a central element for the metabolic syndrome. However,
it is not well established whether human subcutaneous adipose tissue is affected by or affect …

Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its
related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 …

Background Obesity is a well-recognized risk factor for insulin resistance and type 2
diabetes (T2D), although the precise mechanisms underlying the relationship remain …

Background The high prevalence of obesity among US adults has resulted in significant
increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood …

The recent increase in obesity levels across many countries is likely to be driven by
nongenetic factors. The epigenetic modification DNA methylation (DNAm) may help to …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Background Obesity and type 2 diabetes (T2D) are major public health issues worldwide,
and put a significant burden on the healthcare system. Genetic variants, along with …

Background The current epidemic of obesity and associated diseases calls for swift actions
to better understand the mechanisms by which genetics and environmental factors affect …