Background Obesity is accompanied by excess adipose fat storage, which may lead to
adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency …

Childhood obesity remains an epidemic in the US and worldwide. However, little is
understood regarding the epigenetic basis of obesity in adolescents. To investigate the …

Objective Obesity is driven by modifiable lifestyle factors whose effects may be mediated by
epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in …

Besides differential methylation, DNA methylation variation has recently been proposed and
demonstrated to be a potential contributing factor to cancer risk. Here we aim to examine …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

Background Little is currently known about epigenetic alterations associated with body
composition in obesity. Thus, we aimed to explore epigenetic relationships between …

Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes,
cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic …

Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors for all-cause mortality,
cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS …

Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …

Background Metabolic diseases such as obesity are known to be driven by both
environmental and genetic factors. Although genome-wide association studies of common …