Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects
AB Crujeiras, A Diaz-Lagares… - Translational …, 2016 - Elsevier
Elucidating the potential mechanisms involved in the detrimental effect of excess body
weight on insulin action is an important priority in counteracting obesity-associated …
weight on insulin action is an important priority in counteracting obesity-associated …
Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes
R Ribel-Madsen, MF Fraga, S Jacobsen… - PloS one, 2012 - journals.plos.org
Background Monozygotic twins discordant for type 2 diabetes constitute an ideal model to
study environmental contributions to type 2 diabetic traits. We aimed to examine whether …
study environmental contributions to type 2 diabetic traits. We aimed to examine whether …
In epigenomic studies, including cell-type adjustments in regression models can introduce multicollinearity, resulting in apparent reversal of direction of association
Background: Association studies of epigenome-wide DNA methylation and disease can
inform biological mechanisms. DNA methylation is often measured in peripheral blood, with …
inform biological mechanisms. DNA methylation is often measured in peripheral blood, with …
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue
Genetic variants that associate with DNA methylation at CpG sites (methylation quantitative
trait loci, meQTLs) offer a potential biological mechanism of action for disease associated …
trait loci, meQTLs) offer a potential biological mechanism of action for disease associated …
Body mass index drives changes in DNA methylation: a longitudinal study
Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance
A sustained activation of the unfolded protein response and the subsequent endoplasmic
reticulum (ER) stress has been involved in the onset and severity of several metabolic …
reticulum (ER) stress has been involved in the onset and severity of several metabolic …
The potential of DNA methylation as a biomarker for obesity and smoking
A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study
Background—Genetic research regarding blood lipids has largely focused on DNA
sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of …
sequence variation; few studies have explored epigenetic effects. Genome-wide surveys of …
The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers
Background DNA methylation is associated with body mass index (BMI), but it is not clear if
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
[HTML][HTML] Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice
Heritable epigenetic factors can contribute to complex disease etiology. Here we examine
the contribution of DNA methylation to complex traits that are precursors to heart disease …
the contribution of DNA methylation to complex traits that are precursors to heart disease …