The same mechanisms that enable host defense against helminths also drive allergic
inflammation. This suggests that pathomechanisms of allergic diseases represent …

Developed countries are suffering from an epidemic rise in immunologic disorders, such as
allergy-related diseases and certain autoimmunities. Several studies have demonstrated a …

Inflammatory diseases are on the rise in westernized countries, but also in urbanized areas
of developing countries. A number of studies have now demonstrated a negative association …

Allergic diseases are increasing at an alarming rate worldwide, particularly in developed
countries. In contrast, there is a decrease in the prevalence of helminthic infections and …

Allergic diseases are on the increase globally in parallel with a decrease in parasitic
infection. The inverse association between parasitic infections and allergy at an ecological …

Highlights•Infections with parasitic helminths (worms) may protect against development of
inflammatory and allergic diseases.•Helminths infections promote regulatory immune cell …

There is no immunological mechanism to adequately explain the sudden epidemic in
allergies noted in the last 30 years in developed countries. The reduction in the …

The profile of global health today presents a striking reciprocal distribution between parasitic
diseases in many of the world's lower-income countries, and ever-increasing levels of …

There is increasing interest in helminth parasite modulation of the immune system, both from
the fundamental perspective of the “arms race” between host and parasite, and equally …

Toll-like receptors (TLRs) are essential components of the innate immune system. They play
an important role in the pathogenesis of allergic diseases, especially asthma. Since TLRs …