Randall's plaques (RP) are well established as precursor lesions of idiopathic calcium
oxalate (CaOx) stones, and the process of biomineralization driven by osteogenic-like cells …

Randall's plaque (RP) serves as a nidus on which idiopathic calcium oxalate stones form.
Renal interstitial mineralization may be the cause underlying RP, and recent studies …

Augmented Wnt signaling has been implicated in many fibrotic diseases including
obstructive nephropathy. Soluble form Klotho has been reported to function as a secreted …

Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging
and CKD are not well understood. The antiaging protein Klotho may be an endogenous …

Fibrosis is a pathological process characterized by infiltration and proliferation of
mesenchymal cells in interstitial space. A substantial portion of these cells is derived from …

Background Klotho is a multifunctional protein, which exists both in a membrane bound and
a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response …

Renal fibrosis is an irreversible and progressive process that causes severe dysfunction in
chronic kidney disease (CKD). The progression of CKD stages is highly associated with a …

Klotho is a protein primarily expressed in renal tubular epithelial cells. Studies have
suggested that Klotho is an antiaging protein that reduces renal fibrosis after acute kidney …

Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease
worldwide and is associated with glomerular mesangial cell (MC) proliferation and …

Calcium oxalate (CaOx) is a major contributor to urolithiasis, one of the most common
urological diseases. Our previous study has shown that Klotho rs3752472 polymorphism …