Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its
development and progression are significantly affected by epigenetic modifications such as …

The development of vascular calcification (VC) in chronic uremia (CU) is a tightly regulated
process controlled by factors promoting and inhibiting mineralization. Next-generation high …

Background The current belief is that Randall's plaques (RP) constitute a nidus for the
formation of idiopathic calcium oxalate stones, but the upstream events in RP formation …

Bone loss and increased fracture are the devastating outcomes of chronic kidney disease-
mineral and bone disorder (CKD-MBD) resulting from Klotho deficit-related mineral …

Loss of Klotho and activation of the renin-angiotensin system (RAS) are common
pathological findings in chronic kidney diseases. However, whether these two events are …

Klotho is a recently discovered anti-aging gene and is primarily expressed in kidneys. In
humans, the klotho level decreases with age whereas the prevalence of chronic kidney …

Background Alpha-klotho (α-KL) is not only related to the regulation of calcium-phosphorus
metabolism, and fibrosis in chronic kidney disease (CKD), it is also involved in the regulation …

There are few studies on the effect of klotho on podocytes in diabetic nephropathy. Thus, we
tested whether klotho exerts a protective effect against glomerular injury in diabetes. Mouse …

Klotho is an anti-aging gene that shortens the life span when disrupted and extends the
lifespan when overexpressed. This study investigated whether autophagy plays a role in …

Klotho knock-out mice are an important model for vascular calcification, which is associated
with chronic kidney disease. In chronic kidney disease, serum magnesium inversely …