Background: Low maternal choline intake and blood concentration may be risk factors for
having a child with a neural tube defect (NTD); however, the data are inconsistent. This is an …

Background: Folic acid is known to reduce risk of neural tube defects (NTDs). Even so, NTDs
continue to occur despite individual supplementation or population fortification with folic …

Background Low maternal intake of dietary choline and betaine (a choline derivative) has
recently been investigated as a possible risk factor for neural tube defects (NTDs) Methods …

Periconceptional intake of folic acid prevents some neural tube defects (NTDs). Other
nutrients may also contribute to NTD etiologies; a likely candidate is choline. Similar to folic …

We studied associations between prenatal and early postnatal choline intake, brain
development, and neurocognitive function of children. We conducted a systematic review …

Neural tube defects (NTDs) are common, costly, and oftentimes lethal human congenital
malformations whose etiologies remain poorly understood. Without accounting for the small …

Abstract Background Neural tube defects (NTDs) are among the most common of all human
congenital defects. Over the last two decades, accumulating evidence has made it clear that …

Background: Choline deficiency during pregnancy can lead to adverse birth outcomes,
including impaired neurodevelopment and birth defects. Genetic variants of choline and one …

Choline, an essential nutrient, is pivotal in supporting maternal and fetal health during
pregnancy. In this comprehensive review, we explore the current evidence and the …

Choline has several important functions. It is a source of methyl groups needed to make the
primary methyl donor, S-adenosylmethionine; a part of the neurotransmitter acetylcholine; …