Neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and SIRT1 …

AA Sedik, DT Hussein, K Fathy, NA Mowaad - Scientific Reports, 2024 - nature.com
Acute liver injury, there is a risky neurological condition known as hepatic encephalopathy
(HE). Herbacetin is a glycosylated flavonoid with many pharmacological characteristics. The …

Hepatoprotective and cognitive-enhancing effects of hesperidin against thioacetamide-induced hepatic encephalopathy in rats

NFA El-Magd, DH El-Kashef, M El-Sherbiny, SM Eraky - Life Sciences, 2023 - Elsevier
Hepatic encephalopathy (HE) is a serious neurological disorder which might occur in both
acute and chronic liver injury. Aims: This study was carried out to explore the protective …

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling …

HA Ogaly, RF Abdel-Rahman, MAE Mohamed… - Food & Function, 2022 - pubs.rsc.org
In the present study, we aimed to delineate the neuroprotective potential of thymol (THY)
against neurotoxicity and cognitive deterioration induced by thioacetamide (TAA) in an …

Naringenin mitigates thioacetamide-induced hepatic encephalopathy in rats: Targeting the JNK/Bax/caspase-8 apoptotic pathway

SM Eraky, DH El-Kashef, M El-Sherbiny… - Food & Function, 2023 - pubs.rsc.org
Hepatic encephalopathy (HE) is a serious neurological disorder which is related to liver
dysfunction. HE was induced by thioacetamide (TAA) injection (350 mg kg− 1, ip) for 3 …

Flavonoids from Barnebydendron riedelii leaf extract mitigate thioacetamide-induced hepatic encephalopathy in rats: The interplay of NF-κB/IL-6 and Nrf2/HO-1 …

SM Baraka, DO Saleh, NS Ghaly, FR Melek… - Bioorganic …, 2020 - Elsevier
Phytochemical investigation of the butanol fraction (BUF) derived from the 70% aqueous
methanolic leaf extract of Barnebydendron riedelii led to the isolation of three flavonoid …

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction …

HMA Khalil, HA Eliwa, RA El-Shiekh… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Ashwagandha (ASH) is one of the medicinal plants used
in traditional Indian, Ayurvedic, and Unani medicines for their broad range of …

Syringic acid protects against thioacetamide-induced hepatic encephalopathy: behavioral, biochemical, and molecular evidence

IF Okkay, U Okkay, OL Gundogdu, C Bayram… - Neuroscience …, 2022 - Elsevier
The objective of this study was to elucidate the effects of syringic acid on thioacetamide-
induced hepatic encephalopathy which is a complex serious syndrome with …

Protective role of chrysin on thioacetamide-induced hepatic encephalopathy in rats

SA El-Marasy, SA El Awdan… - Chemico-Biological …, 2019 - Elsevier
Hepatic encephalopathy (HE) is a serious neuropsychiatric syndrome due to either acute or
chronic hepatic failure. This study aimed to investigate the possible neuroprotective effect of …

Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural …

NA Afifi, A Ramadan, EY Erian, AA Sedik… - Canadian journal of …, 2021 - cdnsciencepub.com
Hepatic encephalopathy depicts the cluster of neurological alterations that occur during
acute or chronic hepatic injury. Hyperammonemia, inflammatory injury, and oxidative stress …

Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy in rats

K Ramakrishna, S Sinku, S Majumdar, N Singh… - Toxicology, 2023 - Elsevier
Abstract Indole-3-carbinol (I3C) is reported to have hepatic and neuroprotective properties.
However, the I3C role in the protection of the liver and brain in the pathological condition of …