Epidemiological evidence implies a role for chronic stress and stress-related disorders in the
etiopathogenesis of sporadic Alzheimer's disease (AD). Although chronic stress exposure …

How excessive stress and cortisol exposure predispose people to clinical Alzheimer's
disease (AD) is a matter of great potential medical impact. We discuss recent findings …

Aberrant cortisol and activation of the glucocorticoid receptor (GR) play an essential role in
age-related progression of Alzheimer's disease (AD). However, the GR pathways required …

Age remains the main risk factor for developing Alzheimer's disease (AD) although certain
metabolic alterations, including prediabetes and hyperinsulinemia, also increase this risk …

There is much interest in understanding the mechanisms responsible for interactions among
stress, aging, memory and Alzheimer's disease. Glucocorticoid secretion associated with …

Memory loss is the most prominent clinical aspect of Alzheimer's disease (AD) but, as recent
clinical evidence has been revealed, intervening when memory difficulties are already …

Abstract Alzheimer's disease (AD), the commonest progressive neurodegenerative disorder
of the brain, is clinically characterized by the formation of extracellular amyloid plaques and …

Clinical studies have found that some Alzheimer's disease (AD) patients suffer from
Cushing's syndrome (CS). CS is caused by the long-term release of excess glucocorticoids …

Diabesity-associated metabolic stresses modulate the development of Alzheimer's disease
(AD). For further insights into the underlying mechanisms, we examine whether the genetic …

The progression of Alzheimer's disease (AD) has a silent phase that predates characteristic
cognitive decline and eventually leads to active cognitive deficits. Metabolism, diet, and …