Diabesity-associated metabolic stresses modulate the development of Alzheimer's disease
(AD). For further insights into the underlying mechanisms, we examine whether the genetic …

Patients with Alzheimer's disease (AD) exhibit alterations in glucose metabolism and
dysregulation of the stress-responsive hypothalamic-pituitary-adrenal (HPA) …

Growing evidence indicates that physical and psychosocial stressors, in part acting through
the hypothalamic-pituitary-adrenal (HPA) axis, may accelerate the process of Alzheimer's …

Approximately two-thirds of those suffering with Alzheimer's disease (AD) are women,
however, the biological mechanisms underlying this sex divergence of AD prevalence …

Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but
are also associated with normal aging, albeit less severely. Insulin resistance in the brain …

Mostly Alzheimer's disease (AD) cases are sporadic, with no clear intrinsic triggering
mechanisms but with identified risk factors. Environmental stress factors are thought to …

With disease-modifying treatments for Alzheimer's disease (AD) still elusive, the search for
alternative intervention strategies has intensified. Growing evidence suggests that …

Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has important
health and economic impacts in the elderly. Despite a better understanding of the molecular …

Life-time experiences are thought to influence the risk to develop the neurodegenerative
disorder Alzheimer's disease (AD). In particular, early-life stress (ES) may modulate the …