Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and
alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key …

Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse
neurobiological processes including brain development, synaptogenesis, and myelination …

The G protein-coupled receptor (GPCR) superfamily is the largest known receptor family in
the human genome. Although the family of adhesion GPCRs comprises the second largest …

Adhesion G protein-coupled receptors (aGPCRs) comprise the second largest yet least
studied class of the GPCR superfamily. aGPCRs are involved in many developmental …

Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse biological
processes, including neurodevelopment and cancer progression. aGPCRs are …

Abstract GPR126 (ADGRG6) is an adhesion G protein–coupled receptor that plays an
important role in a variety of tissues/organs, such as heart, sciatic nerve, cartilage, and ear …

Mutations in the G protein–coupled receptor GPR126/ADGRG6 cause human diseases,
including defective peripheral nervous system (PNS) myelination. To study GPR126 …

We recently demonstrated that GPR133 (ADGRD1), an adhesion G protein–coupled
receptor involved in raising cytosolic cAMP levels, is necessary for growth of glioblastoma …

Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
attractive targets for various diseases. aGPCRs are also known to be capable of self …

Despite their abundance and multiple functions in a variety of organ systems, the function
and signaling mechanisms of adhesion G protein-coupled receptors (GPCRs) are poorly …