To characterize the time course of the behavioral and biochemical aspects of the
cannabinoid withdrawal syndrome, we injected the cannabinoid antagonist SR141716A (5 …

Although tolerance to cannabinoids has been well established, the question of cannabinoid
dependence had been very controversial until the discovery of a cannabinoid antagonist …

Rationale Previous reports shows rimonabant's inverse properties may be a limiting factor
for treating cannabinoid dependence. To overcome this limitation, neutral antagonists were …

The availability of the cannabinoid antagonist, SR 141716A, to precipitate withdrawal
following repeated cannabinoid administration provides a model to investigate the …

Whether chronic cannabinoid consumption produces a dependent state comparable to that
occurring with other drugs (eg the appearance of withdrawal signs when consumption is …

Precipitated withdrawal in rats chronically exposed to Δ9-tetrahydrocannabinol, the major
psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first …

This study examined behavioural signs that occur during tolerance development to
cannabinoid treatment and hormonal and gene expression alterations induced by …

Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in …

Chronic exposure to CP55, 940 produced a significant down‐regulation of cannabinoid
receptors in the striatum, cortex, hippocampus, and cerebellum of rat brain. At 24 h after …

Rationale: There is evidence that cannabinoids cause tolerance and physical dependence
in humans and animals. Objectives: The aim of this work was to study whether the …