The precise pathomechanisms of human autoimmune diseases are still poorly understood.
However, a deepened understanding of these is urgently needed to improve disease …

Until recently, autoimmune diseases had been categorized as either Th1-or Th2-mediated
diseases. However, the discovery of a novel subset of helper T cells producing interleukin …

Systemic autoimmune diseases such as systemic lupus erythematosus are type I IFN‐driven
diseases with exaggerated B‐cell responses and autoantibody production. T h17 cells, a T …

Rheumatoid arthritis (RA) is one of the most common autoimmune disorders characterized
by the chronic and progressive inflammation of various organs, most notably the synovia of …

A more complete understanding of the mechanisms that drive autoimmune diseases has
begun to be translated into therapeutic options with significant clinical consequences. A …

Abstract Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA) are amongst the most
common autoimmune diseases in the northern hemisphere. There is mounting evidence that …

The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the
adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17' …

Recent studies demonstrated an IL-17-producer CD4+ T cell subpopulation, termed Th17,
distinct from Th1 and Th2. It represents a different pro-inflammatory Th-cell lineage. This …

Abstract OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON Th17 CELLS
Function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol …

With all the incredible progress in scientific research over the past two decades, the trigger
of the majority of autoimmune disorders remains largely elusive. Research on the biology of …