Experimental animal models of neoplastic diseases are important in understanding
etiological and pathophysiological processes also in humans. In order to investigate …

Microsatellite instability in rat colon tumors induced by heterocyclic amines was examined
by studies on the lengths of 85 microsatellite sequences, covering most of the rat …

Publisher Summary This chapter focuses on the pathways of chromosome alteration in
human epithelial cancers. The existence of distinct pathways of chromosomal evolution in …

The majority of tumors associated with thenonpolyposisform of familial colorectal cancer
(HNPCC) shows a specific form of genetic instability which is manifested by length …

Microsatellite instability (MSI) is caused by DNA mismatch repair deficiency and is an
important prognostic and predictive biomarker in colorectal cancer but relatively few studies …

Cell-free DNA in the blood of cancer patients has been shown to harbor microsatellite
alterations frequently matching those of the primary tumors. The aim of this study was to …

Tumorigenesis has been shown to proceed through a series of genetic alterations involving
protooncogenes and tumor-suppressor genes. Investigation of genomic instability of …

For a normal cell to accumulate multiple genetic changes during multistage carcinogenesis,
the induction of genomic instability is considered advantageous. Since most human cancers …

Alterations in the length of simple repetitive genomic sequences (microsatellite instability,
MSI) may characterize a distinct mechanism of mammary carcinogenesis. In order to …

Two apparently independent mechanisms of instability are recognized in colorectal cancer,
microsatellite instability and chromosomal instability. Evidence from colorectal cancer cell …