We have previously reported the development of a transgenic mouse model for prostate
cancer derived from PB-Tag transgenic line 8247, henceforth designated the TRAMP …

BACKGROUND Adenocarcinoma of the prostate is the most common cancer in American
men. It is estimated that in 1996 pros-tate cancer will account for over 40,000 deaths and …

The transgenic adenocarcinoma of the mouse prostate (TRAMP) model closely mirrors the
pathogenesis of human prostate cancer. Male TRAMP mice uniformly and spontaneously …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

To develop a syngeneic transplantable system to study immunotherapeutic approaches for
the treatment of prostate cancer, three cell lines were established from a heterogeneous 32 …

This review is focused on mouse models for prostate cancer that have been designed on the
basis of genetic alterations that are frequently found in human prostate cancer. It begins with …

Background Animal models that closely mimic clinical disease can be exploited to hasten
the pace of translational research. To this end, we have defined windows of opportunity in …

The ability to manipulate gene expression in specific cell types at specific times utilizing
transgenic technology has allowed the development of novel mouse model systems that can …

We previously established the autochthonous transgenic adenocarcinoma mouse prostate
(TRAMP) model to facilitate characterization of molecular mechanisms involved in the …

Metastasis is the major cause of prostate cancer deaths and there is a need for clinically
relevant in vivo models allowing elucidation of molecular and cellular mechanisms …