We show here that expression of genes from convergent transcription units can be regulated
by the formation of double-stranded RNA (dsRNA) in the region of overlapping …

Mouse polyomavirus contains a circular DNA genome, with early and late genes transcribed
from opposite strands. At early times after infection, genes encoded from the early …

Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control
gene expression. Like alternative splicing, usage of alternative poly (A) sites allows a single …

Alternative polyadenylation (APA) produces from the same gene multiple mature RNAs with
varying 3′ ends. Although APA is commonly believed to generate beneficial functional …

Recent research has uncovered extensive variability in the boundaries of transcript isoforms,
yet the functional consequences of this variation remain largely unexplored. Here, we …

The processing of the proximal and distal poly (A) sites in alternative polyadenylation (APA)
has long been thought to independently occur on pre-mRNAs during transcription. However …

Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites,
express mRNA isoforms with variable 3′ untranslated regions (UTRs). By systematic …

Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …

Changing the position of the poly (A) tail in an mRNA—alternative polyadenylation—is an
important mechanism to increase the diversity of gene expression, especially in metazoans …

The relationship between polyadenylation and splicing was investigated in a model system
consisting of two tandem but nonidentical polyomavirus late transcription units. This model …