Metabolic alterations are one of the hallmarks of cancer, which has recently gained great
attention. Increased glucose absorption and lactate secretion in cancer cells are …

Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the
Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to …

Several decades ago, Otto Warburg discovered that cancer cells produce energy
predominantly by glycolysis; a phenomenon now termed “Warburg effect”. Warburg linked …

Cancer metastasis is the major cause of cancer-associated death. Accordingly, identification
of the regulatory mechanisms that control whether or not tumor cells become “directed …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

The Warburg effect, the propensity of some cells to metabolize glucose to lactate in the
presence of oxygen (also known as aerobic glycolysis), has long been observed in cancer …

In differentiated normal cells, the conventional route of glucose metabolism involves
glycolysis, followed by the citric acid cycle and electron transport chain to generate usable …

Cancer cells require a steady source of metabolic energy in order to continue their
uncontrolled growth and proliferation. Accelerated glycolysis is one of the biochemical …

Low oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus
that metazoan organisms have contended with since they evolved from their single-celled …