It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

In differentiated normal cells, the conventional route of glucose metabolism involves
glycolysis, followed by the citric acid cycle and electron transport chain to generate usable …

Cancer cells require a steady source of metabolic energy in order to continue their
uncontrolled growth and proliferation. Accelerated glycolysis is one of the biochemical …

Low oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus
that metazoan organisms have contended with since they evolved from their single-celled …

Cancer metabolism has emerged as an important area of research in recent years.
Elucidation of the metabolic differences between cancer and normal cells and the …

Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their
intracellular alkaline pH (pH i). This effect is part of the metabolic alterations found in most, if …

In 1923, Otto Warburg published his landmark study, in which he described his seminal
observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His …

Simple Summary This comprehensive review discusses the anticancer effects of plant
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …

Post-translational modification (PTM) is an important step of signal transduction that
transfers chemical groups such as phosphate, acetyl and glycosyl groups from one protein …

Metastatic tumors generally exhibit aerobic glycolysis (the Warburg effect). The advent of [18
F] fluorodeoxyglucose positron emission tomography imaging, coupled with recent findings …