Cetuximab in the management of locoregionally advanced head and neck cancer: expanding the treatment options?

J Bourhis, JL Lefebvre, JB Vermorken - European Journal of Cancer, 2010 - Elsevier
The treatment of locoregionally advanced squamous cell carcinoma of the head and neck
(SCCHN) has evolved in recent years as a consequence of a better understanding of the …

Cetuximab combined with radiotherapy: an alternative to chemoradiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck?

J Bernier, D Schneider - European Journal of Cancer, 2007 - Elsevier
Radiotherapy remains the foundation of current treatment for patients with locally advanced
squamous cell carcinoma of the head and neck (SCCHN). It has been shown that the …

Cetuximab in the treatment of head and neck cancer

J Bernier - Expert review of anticancer therapy, 2006 - Taylor & Francis
Approaches to the treatment of locally advanced and recurrent and/or metastatic squamous
cell carcinoma of the head and neck (SCCHN) have been limited by their toxicity. Effective …

Cetuximab: a review of its use in squamous cell carcinoma of the head and neck

JE Frampton - Drugs, 2010 - Springer
Cetuximab (Erbitux®) is a chimeric monoclonal antibody directed against the human
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …

Final results of a randomized phase 2 trial investigating the addition of cetuximab to induction chemotherapy and accelerated or hyperfractionated chemoradiation for …

TY Seiwert, JM Melotek, EA Blair, KM Stenson… - International Journal of …, 2016 - Elsevier
Purpose The role of cetuximab in the treatment of locoregionally advanced head and neck
squamous cell cancer (LA-HNSCC) remains poorly defined. In this phase 2 randomized …

Spotlight on cetuximab in squamous cell carcinoma of the head and necky

JE Frampton - BioDrugs, 2011 - Springer
Cetuximab (Erbitux®) is a chimeric monoclonal antibody directed against the human
epidermal growth factor receptor (EGFR). EGFR is overexpressed and/or upregulated in …

Concurrent cetuximab, cisplatin, and radiotherapy (RT) for loco-regionally advanced squamous cell carcinoma of the head and neck (SCCHN): updated results of a …

YB Su, DH Kraus, MJ Zelefsky, E Lis… - Journal of Clinical …, 2005 - ascopubs.org
5529 Background: We previously reported results of a phase 2 study of concurrent
cetuximab, a chimeric monoclonal antibody directed against the epidermal growth factor …

Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with …

JA Bonner, PM Harari, J Giralt, N Azarnia… - Journal of Clinical …, 2004 - ascopubs.org
5507 Background: The majority of head and neck cancers overexpress the epidermal
growth factor receptor (EGFR), which is associated with aggressive tumor behavior and poor …

The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer

MA Tejani, RB Cohen, R Mehra - Biologics: Targets and Therapy, 2010 - Taylor & Francis
Recurrent and/or metastatic squamous cell carcinoma of the head and neck (HNSCC)
continues to be a source of significant morbidity and mortality worldwide. Agents that target …

Cetuximab: its unique place in head and neck cancer treatment

P Specenier, JB Vermorken - Biologics: Targets and Therapy, 2013 - Taylor & Francis
Head and neck cancer is the sixth most common cancer worldwide. At present, globally
about 650,000 new cases of squamous cell carcinoma of the head and neck (SCCHN) are …