Summary Background The London patient (participant 36 in the IciStem cohort) underwent
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …

Despite scientific evidence originating from two patients published to date that
CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human …

Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32)
allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in …

HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5
or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral …

The main indication for allogeneic HSCT in adults is the diagnosis of AML. In the last
decade, about 3500 new cases of AML have been reported in Germany per year (incidence …

Background. The long-term impact of allogeneic hematopoietic stem cell transplantation
(HSCT) on human immunodeficiency virus type 1 (HIV-1) reservoirs in patients receiving …

A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago,.
The individual—who is known as the 'Berlin patient'—underwent two allogeneic …

There is intense interest in developing curative interventions for HIV. How such a cure will
be quantified and defined is not known. We applied a series of measurements of HIV …

Allogeneic transplantation with CCR5-delta 32 (CCR5-d32) homozygous stem cells in an
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …

Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a
CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5) …