Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy

F Sedaghat-Hamedani, J Haas, F Zhu… - European heart …, 2017 - academic.oup.com
Aims In this study, we aimed to clinically and genetically characterize LVNC patients and
investigate the prevalence of variants in known and novel LVNC disease genes. Introduction …

The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy

YM Hoedemaekers, K Caliskan, M Michels… - Circulation …, 2010 - Am Heart Assoc
Background—Left ventricular (LV) noncompaction (LVNC) is a distinct cardiomyopathy
featuring a thickened bilayered LV wall consisting of a thick endocardial layer with …

Targeted panel sequencing in adult patients with left ventricular non‐compaction reveals a large genetic heterogeneity

P Richard, F Ader, M Roux, E Donal, JC Eicher… - Clinical …, 2019 - Wiley Online Library
Left ventricular non‐compaction (LVNC) is a cardiomyopathy that may be of genetic origin;
however, few data are available about the yield of mutation, the spectrum of genes and …

Left ventricular non-compaction: genetic heterogeneity, diagnosis and clinical course

G Captur, P Nihoyannopoulos - International journal of cardiology, 2010 - Elsevier
Left ventricular non-compaction (LVNC) is a rare disorder that results in multiple deep
trabeculations within the left ventricular myocardium. It is thought to be due in part, to an …

Left ventricular non‐compaction: prevalence in congenital heart disease

BE Stähli, C Gebhard, P Biaggi, S Klaassen… - International journal of …, 2013 - Elsevier
Introduction Left ventricular non-compaction cardiomyopathy (LVNC) is a rare
cardiomyopathy, originally described as an isolated disease without other structural cardiac …

Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype

S Probst, E Oechslin, P Schuler… - Circulation …, 2011 - Am Heart Assoc
Background—Left ventricular noncompaction of the myocardium (LVNC) has been
recognized as a cardiomyopathy with a genetic etiology. Mutations in genes encoding …

Left ventricular noncompaction cardiomyopathy: updated review

DU Udeoji, KJ Philip, RP Morrissey… - Therapeutic …, 2013 - journals.sagepub.com
The first case of noncompaction was described in 1932 after an autopsy performed on a
newborn infant with aortic atresia/coronary–ventricular fistula. Isolated noncompaction …

Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation

M Luedde, P Ehlermann, D Weichenhan… - Cardiovascular …, 2010 - academic.oup.com
Aims Left ventricular non-compaction (LVNC) is caused by mutations in multiple genes. It is
still unclear whether LVNC is the primary determinant of cardiomyopathy or rather a …

Genetics, clinical features, and long-term outcome of noncompaction cardiomyopathy

JI van Waning, K Caliskan, YM Hoedemaekers… - Journal of the American …, 2018 - jacc.org
Background: The clinical outcomes of noncompaction cardiomyopathy (NCCM) range from
asymptomatic to heart failure, arrhythmias, and sudden cardiac death. Genetics play an …

[HTML][HTML] Left ventricular noncompaction− Risk stratification and genetic consideration−

F Ichida - Journal of Cardiology, 2020 - Elsevier
Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by two layered
structures composed of prominent trabecular meshwork and deep intertrabecular recesses …