Previously unreported adverse drug reactions can be difficult to detect and it may be even
more difficult to establish a cause and effect relationship, particularly if the adverse reacions …

This paper reviews the behaviour of intraocular pressure (IOP) in glaucomatous eyes treated
with metipranolol with and without drug-induced adverse reactions (ADRs). Two hundred …

This paper presents for the first time documented evidence, clinical details, and
photographic illustrations of metipranolol-associated granulomatous anterior uveitis in 26 …

Metipranolol hydrochloride is a topical β blocker used in the treatment of glaucoma. It has
been in widespread use throughout Europe since the late 1980s and has recently been …

Five hundred forty-seven reports of adverse reactions to timolol maleate received by the
National Registry for Drug-induced Ocular Side Effects during an eleven-month period were …

SIR,-During 1974 and 1975 the Swedish Adverse Drug Reaction Committee received 95
reports of adverse reactions involving the skin and eyes following treatment with practolol …

Objective: To assess the incidence of uveitis associated with topical β-blockers. Design:
Retrospective cohort study. Setting: A computerized database of a health maintenance …

SIR,-I refer to the articles'2 in which the observation of uveitis in patients being treated for
glaucoma with metipranalol was noted. I wish to report similar findings of uveitis in eight …

In a double-blind controlled study seven healthy subjects with normal eyes were given
alternatively a placebo or 80 or 160 mg of propranolol per day, with an interval of at least 1 …

A review of current literary sources disclosed a host of adverse reactions which may
potentially be associated with the topical administration of timolol maleate. Systemic …