Catecholamine neurons of the locus coeruleus (LC) in the dorsal pontine tegmentum
innervate the entire neuroaxis, with signaling actions implicated in the regulation of …

Alzheimer's disease (AD) is the most common cause of cognitive impairment in older
patients, and its prevalence is expected to soar in coming decades. Neuropathologically, AD …

The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It
becomes activated after arousal and novelty, whereupon noradrenaline is released in the …

MARA MATHER abstract With its extensive projections that release norepinephrine (NE), the
locus coeruleus (LC) has a major influence on the rest of the brain and influences cognitive …

Highlights•Locus Coeruleus noradrenergic system modulates all aspects of memory
processing.•LC most heavily innervates mPFC.•LC reorients attention.•LC activity in tune …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …

Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Alzheimer's disease (AD) represents the most prevalent form of dementia in the elderly.
However, the pathological mechanisms underlying the development and progression of AD …

The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …