Gene mutations impede oocyte maturation, fertilization, and early embryonic development
C Fei, L Zhou - Bioessays, 2022 - Wiley Online Library
Reproductive diseases are a long‐standing problem and have become more common in the
world. Currently, 15% of the world's population suffers from infertility, and half of them are …
world. Currently, 15% of the world's population suffers from infertility, and half of them are …
Genetic factors as potential molecular markers of human oocyte and embryo quality
Q Sang, Z Zhou, J Mu, L Wang - Journal of Assisted Reproduction and …, 2021 - Springer
Successful human reproduction requires gamete maturation, fertilization, and early
embryonic development. Human oocyte maturation includes nuclear and cytoplasmic …
embryonic development. Human oocyte maturation includes nuclear and cytoplasmic …
Genetics of human female infertility
SA Yatsenko, A Rajkovic - Biology of reproduction, 2019 - academic.oup.com
About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …
term. Female factors alone account for at least 35% of all infertility cases and comprise a …
Genetics of mammalian reproduction: modeling the end of the germline
Our understanding of reproduction and early embryonic development has directly enabled
our manipulation of the mouse genome for tests of gene function in vivo. In this review, we …
our manipulation of the mouse genome for tests of gene function in vivo. In this review, we …
The molecular genetics of oogenesis
F Zhai, X Ma, L Yan, J Qiao - Human reproductive and prenatal genetics, 2023 - Elsevier
Oogenesis involves complex differentiation program leading to the production of functional
oocytes. Oogonia originating from primordial germ cells proliferate by mitosis and form …
oocytes. Oogonia originating from primordial germ cells proliferate by mitosis and form …
[PDF][PDF] Mouse models of ovarian failure
JA Elvin, MM Matzuk - Reviews of reproduction, 1998 - scholar.archive.org
Ovarian failure leading to infertility can be caused by improper prenatal development of the
fetal gonad or disruption of the complex postnatal process of folliculogenesis due to …
fetal gonad or disruption of the complex postnatal process of folliculogenesis due to …
[HTML][HTML] Oocyte maturation failure: a syndrome of bad eggs
To show that disruption of meiotic competence results in cell cycle arrest, and the production
of immature oocytes that are not capable of fertilization. Through an extensive review of …
of immature oocytes that are not capable of fertilization. Through an extensive review of …
Insights into primary ovarian insufficiency through genetically engineered mouse models
SD Sullivan, DH Castrillon - Seminars in reproductive medicine, 2011 - thieme-connect.com
Primary ovarian insufficiency (POI), also known as premature ovarian failure, is a form of
hypergonadotropic hypogonadism that causes infertility in~ 1% of women< 40 years of age …
hypergonadotropic hypogonadism that causes infertility in~ 1% of women< 40 years of age …
Ovarian follicle development and transgenic mouse models
KR Barnett, C Schilling, CR Greenfeld… - Human reproduction …, 2006 - academic.oup.com
Ovarian follicle development is a complex process that begins with the establishment of
what is thought to be a finite pool of primordial follicles and culminates in either the atretic …
what is thought to be a finite pool of primordial follicles and culminates in either the atretic …
Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice
SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …