Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease
SS Jiao, LL Shen, C Zhu, XL Bu, YH Liu, CH Liu… - Translational …, 2016 - nature.com
Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the
pathogenesis of Alzheimer's disease (AD), which is characterized with the formation of …
pathogenesis of Alzheimer's disease (AD), which is characterized with the formation of …
Brain-derived neurotrophic factor in Alzheimer's disease: risk, mechanisms, and therapy
JH Song, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease
Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …
Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by aβ1-42
An emerging body of data suggests that the early onset of Alzheimer's disease (AD) is
associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays …
associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays …
Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential
L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …
arise as the disease progresses. A growing body of evidence suggests that pathological …
Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice
GJ Burbach, R Hellweg, CA Haas… - Journal of …, 2004 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is a versatile neurotrophic factor that has been
implicated in cell survival, cell differentiation, axonal growth, and activity-dependent synaptic …
implicated in cell survival, cell differentiation, axonal growth, and activity-dependent synaptic …
Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in …
DJ Garzon, M Fahnestock - Journal of Neuroscience, 2007 - Soc Neuroscience
Alzheimer's disease (AD) is a senile dementia characterized by amyloid plaques,
neurofibrillary tangles, and synaptic and cell loss. The “amyloid cascade” hypothesis …
neurofibrillary tangles, and synaptic and cell loss. The “amyloid cascade” hypothesis …
Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease
In Alzheimer's disease, soluble tau accumulates and deposits as neurofibrillary tangles
(NFTs). However, a precise toxic mechanism of tau is not well understood. We hypothesized …
(NFTs). However, a precise toxic mechanism of tau is not well understood. We hypothesized …
[HTML][HTML] Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits
G Gerenu, E Martisova, H Ferrero, M Carracedo… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Brain-derived neurotrophic factor (BDNF) plays pivotal roles in neuronal function. The
cleaved–mature–form of BDNF (mBDNF), predominantly expressed in adult brains, critically …
cleaved–mature–form of BDNF (mBDNF), predominantly expressed in adult brains, critically …
Therapeutic potential of neurotrophic factors in Alzheimer's Disease
A Nasrolahi, F Javaherforooshzadeh… - Molecular biology …, 2022 - Springer
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the
most common cause of dementia among the elderly population. AD is accompanied with the …
most common cause of dementia among the elderly population. AD is accompanied with the …