Background strain is known to influence the way a genetic manipulation affects mouse
phenotypes. Despite data that demonstrate variations in the primary phenotype of basic …

C57BL/6J mice were fed a high-fat, carbohydrate-free diet (HFD) for 9 mo. Approximately
50% of the mice became obese and diabetic (ObD),∼ 10% lean and diabetic (LD),∼ 10 …

Decreased metabolic flexibility, ie a compromised ability to adjust fuel oxidation to fuel
availability supports development of adverse consequences of obesity. The aims of this …

OBJECTIVE—To characterize differences in whole-body glucose metabolism between
commonly used inbred mouse strains. RESEARCH DESIGN AND METHODS …

Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …

We have previously shown that the C57BL/6J (B6) mouse will develop obesity and diabetes
if raised on a high-fat diet. Because high fat feeding is associated with hyperphagia, the …

Although it is now becoming more evident that the strain of mouse used to generate
genetically modified models for the study of endocrine disorders contributes to the ensuing …

Glucose metabolism and insulin sensitivity in the skeletal muscle of genetically obese-
diabetic mice (db/db) 5-6 wk of age (an early stage of the diabetes-obesityc syndrome) were …

We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if
weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The …

Modern genetics has developed methods to modify the expression of genes in animals to
study the factors responsible for the tissue-specific expression and hormonal and dietary …