Since the publication of the Janeway's Pattern Recognition hypothesis in 1989, study of
pathogen-associated molecular patterns (PAMPs) and their immuno-stimulatory activities …

The innate immune system has the capacity to recognize a wide range of pathogens based
on conserved PAMPs (pathogen-associated molecular patterns). In the case of bacterial …

The dominant conceptual framework for understanding innate immunity has been that host
cells respond to evolutionarily conserved molecular features of pathogens called pathogen …

Major advances have recently been achieved in the area of microbial recognition by the
innate immune system. In this Forum, we discuss important issues related to innate …

Innate immune system is the first line of host defense against invading microorganisms. It
relies on a limited number of germline-encoded pattern recognition receptors that recognize …

The immune system detects “danger” through a series of what we call pathogen-associated
molecular patterns (PAMPs) or damage-associated molecular pattern molecules (DAMPs) …

Much is known about both microbial virulence and host defense mechanisms, and yet how
they interact to produce different clinical outcomes is poorly appreciated. Here I review …

The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

The molecular mechanisms that have been designed to protect the host from invading
pathogens are responsible for sepsis, an often fatal response of the immune system against …

The study of innate immunity to bacteria has focused heavily on the mechanisms by which
mammalian cells detect lipopolysaccharide (LPS), the conserved surface component of …