Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in …
Z Xie, L Huang, B Enkhjargal, C Reis, W Wan… - Brain, behavior, and …, 2018 - Elsevier
Neuroinflammation is an essential mechanism involved in the pathogenesis of
subarachnoid hemorrhage (SAH)-induced brain injury. Recently, Netrin-1 (NTN-1) is well …
subarachnoid hemorrhage (SAH)-induced brain injury. Recently, Netrin-1 (NTN-1) is well …
Netrin‐1 alleviates subarachnoid haemorrhage‐induced brain injury via the PPAR γ/NF‐KB signalling pathway
J Chen, Y Xuan, Y Chen, T Wu, L Chen… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract Netrin‐1 (NTN‐1) is a novel drug to alleviate early brain injury following
subarachnoid haemorrhage (SAH). However the molecular mechanism of NTN‐1‐mediated …
subarachnoid haemorrhage (SAH). However the molecular mechanism of NTN‐1‐mediated …
[HTML][HTML] Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice
Background Netrin-1 functions largely via combined receptors and downstream effectors.
Evidence has shown that astrocytes express netrin-1 receptors, including DCC and …
Evidence has shown that astrocytes express netrin-1 receptors, including DCC and …
Intranasal administration of recombinant Netrin-1 attenuates neuronal apoptosis by activating DCC/APPL-1/AKT signaling pathway after subarachnoid hemorrhage in …
Z Xie, L Huang, B Enkhjargal, C Reis, W Wan, J Tang… - …, 2017 - Elsevier
Neuronal apoptosis is a crucial pathological process in early brain injury after subarachnoid
hemorrhage (SAH). The effective therapeutic strategies to ameliorate neuronal apoptosis …
hemorrhage (SAH). The effective therapeutic strategies to ameliorate neuronal apoptosis …
[HTML][HTML] Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-κB signaling
X Zhang, J Li, C Cao, Z Liu, Q Chen, Z Gu… - International …, 2024 - Elsevier
Oxidative stress and neuroinflammation are two major causes leading to early brain injury
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …
after subarachnoid hemorrhage (SAH). Nuclear factor E2-related factor 2 (Nrf2) is a critical …
[HTML][HTML] NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral …
X Wu, S Fu, Y Liu, H Luo, F Li, Y Wang, M Gao… - Journal of …, 2019 - Springer
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …
Netrin‐1 preserves blood‐brain barrier integrity through deleted in Colorectal Cancer/Focal Adhesion kinase/RhoA signaling pathway following subarachnoid …
Z Xie, B Enkhjargal, C Reis, L Huang… - Journal of the …, 2017 - Am Heart Assoc
Background Netrin‐1 (NTN‐1) has been established to be a novel intrinsic regulator of
blood‐brain barrier (BBB) maintenance. This study was carried out to investigate the …
blood‐brain barrier (BBB) maintenance. This study was carried out to investigate the …
[HTML][HTML] NEK7 coordinates rapid neuroinflammation after subarachnoid hemorrhage in mice
G Li, Y Dong, D Liu, Z Zou, G Hao, X Gao, P Pan… - Frontiers in …, 2020 - frontiersin.org
Background: Subarachnoid hemorrhage (SAH) is a devastating disease which leads to high
morbidity and mortality. Recent studies have indicated that, never in mitosis gene A-related …
morbidity and mortality. Recent studies have indicated that, never in mitosis gene A-related …
[HTML][HTML] Netrin-1 controls inflammation in response to ischemic stroke through altering microglia phenotype
X Yang, Y Liu, W Zhong, Y Li, W Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Introduction The current approaches that are used to treat ischemic stroke suffer from poor
targeting, lack of effectiveness, and potential off-target effects, necessitating the …
targeting, lack of effectiveness, and potential off-target effects, necessitating the …
The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling
J Qiu, M Wang, J Zhang, Q Cai, D Lu, Y Li… - International …, 2016 - Elsevier
Neuroinflammation remains the primary cause of morbidity and mortality in stroke-induced
secondary brain injury. The NOD-like receptor pyrin 3 (NLRP3) inflammasome is involved in …
secondary brain injury. The NOD-like receptor pyrin 3 (NLRP3) inflammasome is involved in …
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