Cholinergic receptor activation leads to premature development of hypertension and
infiltration of proinflammatory CD161a+/CD68+ M1 macrophages into the renal medulla …

Rationale: Inflammation and adaptive immunity play a crucial role in the development of
hypertension. Angiotensin II and probably other hypertensive stimuli activate the central …

Rationale: Renal inflammation contributes to the pathophysiology of hypertension. CD161a+
immune cells are dominant in the (SHR) spontaneously hypertensive rat and expand in …

488 Circulation Research August 28, 2015 proinflammatory cytokines interleukin (IL)-1α, IL-
1β, IL-2, and IL-6, are key modulators of renal injury in hypertension. The IL-1 family …

Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension;
however, the therapeutic mechanisms remain unclear. Efferent renal sympathetic nerve …

Recent reports indicate that, in addition to treating hypertension, renal denervation (RDN)
also mitigates renal inflammation. However, because RDN decreases renal perfusion …

There is good evidence for a causal link between excessive sympathetic drive to the kidney
and hypertension. We hypothesized that sympathetic regulation of tubular Na+ absorption …

Overactivation of renal sympathetic nervous system and low-grade systemic inflammation
are common features of hypertension. Renal denervation (RDN) reduces sympathetic …

Increasing evidence shows that antigen-presenting cells (APCs) are involved in the
development of inflammation associated to hypertension. However, the potential role of …

Increasing evidence indicates that inflammation of visceral organs is significantly affected by
the autonomic nervous system. Such neuroimmune interactions have not been studied in …