Since the discovery of endothelin (ET)‐1 in 1988, the main components of the signalling
pathway have become established, comprising three structurally similar endogenous 21 …

The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …

In humans, the endothelins (ETs) comprise a family of three 21-amino-acid peptides, ET-1,
ET-2 and ET-3. ET-1 is synthesised from a biologically inactive precursor, Big ET-1, by an …

Endothelins (ETs) are potent vasoconstrictor peptides and are associated with several
disease states like pulmonary hypertension, systemic hypertension and heart failure …

There is considerable evidence that the potent vasoconstrictor endothelin‐1 (ET‐1)
contributes to the pathogenesis of a variety of cardiovascular diseases. As such …

The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …

Endothelin (ET), a 21-amino acid peptide secreted by the vascular endothelial cells, is
frequently reported to be one of the most potent vasoconstrictors. ET induces endothelial …

Endothelin (ET)‐1 is an endothelium‐derived peptide with potent vasoconstrictor and
proliferative properties. The ET system is activated in several cardiovascular disease states …

Meeting REPORT demonstrating that ETB receptor stimulation by sarafotoxin 6c (S6c) can
also increase the secretion of adrenomedullin, a circulating vasodilatory and natriuretic …

Cardiovascular disease is a major contributor to global morbidity and mortality and is the
common end point of many chronic diseases. The endothelins comprise three structurally …