BACKGROUND OF INVENTION [0002] Targeted delivery of therapeutic and diagnostic
agents has largely relied on associating the agent with a targeting molecule that binds to an …

5,503,627 A 4/1996 McKinnon etal. 6,399,754 B1 6/2002 C001< _ 5,512,600 A 4/1996
M1kose1a1. 6,403,779 B1 6/2002 Kawasakl et al. 5,514,378 A 5/1996 M1koseta1 …

INTRODUCTION [0003] Targeted delivery of a therapeutic molecule to a target cell is highly
desirable due to the associated advan tages. For example, if a therapeutic molecule can be …

BACKGROUND OF INVENTION cohesin ligand-binding domain. In some embodiments, the
ligand comprises a dockerin domain. Targeted delivery of therapeutic and diagnostic agents …

The present invention is directed to a molecular delivery vehicle for delivery of compounds
to a target, comprising:(a) a carrier for carrying the compounds;(b) an adapter covalently …

0001. This application is a continuation-in-part of US application Ser. No. 09/703,474 filed
Oct. 31, 2000, which is a continuation-in-part of US application Ser. No. 09/478, 124, filed …

0002 Targeted delivery of therapeutic agents to brain tis sue or specific cells within the brain
has immense potential for treatment of neurological disease. The structure and compo sition …

Amethod of treating a speci? c site in a mammal With a drug comprises (a) providing a
carrier material Which re? ects or absorbs or emits electromagnetic or mechanical vibrations …

(57) ABSTRACT A therapeutic agent delivery system includes a therapeutic agent delivery
platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of …

The present invention provides a system presenting site-spe cific accumulation through a
ligand that specifically targets a receptor overexpressed on the surface of specific cells …