Observational studies have documented that women take a variety of medications during
pregnancy. It is well known that pregnancy can induce changes in the plasma …

Pregnancy is a complex state where changes in maternal physiology have evolved to favor
the development and growth of the placenta and the fetus. These adaptations may affect …

Physiologic changes in pregnancy induce profound alterations to the pharmacokinetic
properties of many medications. These changes affect distribution, absorption, metabolism …

Knowledge of pharmacokinetics and the use of a mechanistic-based approach can improve
our ability to predict the effects of pregnancy for medications when data are limited. Despite …

Background Women are commonly prescribed a variety of medications during pregnancy.
As most organ systems are affected by the substantial anatomical and physiological …

Purpose To critically review pregnancy-induced pharmacokinetic changes and their clinical
application. Methods Structured review of Pubmed, MBASE and published books. Results …

The pharmacokinetics of many drugs are altered by pregnancy. Drug distribution and protein
binding are changed by pregnancy. While some drug metabolizing enzymes have an …

Significant changes in the physiological and biotransformation processes that govern
pharmacokinetics occur during pregnancy. Consequently, the disposition of many …

Background Physiologically based pharmacokinetic modeling is considered a valuable tool
for predicting pharmacokinetic changes in pregnancy to subsequently guide in-vivo …

The dynamic physiological changes that occur in the maternal-placental-fetal unit during
pregnancy influence the pharmacokinetic processes of drug absorption, distribution and …