Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course
H Zhang, X Wu, H Wang, AM Mikheev, Q Mao… - Molecular …, 2008 - ASPET
The plasma concentrations of orally administered anti-human immunodeficiency virus
protease inhibitors are significantly reduced during human and mouse pregnancy. We have …
protease inhibitors are significantly reduced during human and mouse pregnancy. We have …
Efflux transporters of the human placenta
AM Young, CE Allen, KL Audus - Advanced drug delivery reviews, 2003 - Elsevier
The use of pharmaceuticals during pregnancy is often a necessity for the health of the
mother. Until recently, the placenta was viewed as a passive organ through which molecules …
mother. Until recently, the placenta was viewed as a passive organ through which molecules …
Gender differences in pharmacokinetics
CH Gleiter, U Gundert-Remy - European journal of drug metabolism and …, 1996 - Springer
The is growing awareness that the underrepresentation of women in clinical trials and in
particular in phase I studies may lead to incorrect handling of drugs. Despite the fact that …
particular in phase I studies may lead to incorrect handling of drugs. Despite the fact that …
The ontogeny of drug metabolizing enzymes and transporters in the rat
L de Zwart, M Scholten, JG Monbaliu, PP Annaert… - Reproductive …, 2008 - Elsevier
Knowledge of the ontogeny of the various systems involved in distribution and elimination of
drugs is important for adequate interpretation of the findings during safety studies in juvenile …
drugs is important for adequate interpretation of the findings during safety studies in juvenile …
Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy
J Hakkola, H Raunio, R Purkunen, O Pelkonen… - Biochemical …, 1996 - Elsevier
Human first-trimester placentas were screened for the expression of xenobiotic-metabolizing
cytochrome P450 (CYP) genes. mRNAs of CYP1A1, CYP1A2, CYP2C, CYP2D6, CYP2E1 …
cytochrome P450 (CYP) genes. mRNAs of CYP1A1, CYP1A2, CYP2C, CYP2D6, CYP2E1 …